Analiza is a leading provider of physicochemical services to the pharmaceutical industry. Our high throughput work cells provide us with the ability to give you highly accurate and reproducible data at a fraction of the typical CRO costs. Our analytical services include: Thermodynamic or Kinetic Solubility, Log D, pKA (multiplexed CE), Crystallinity Assessment (XRD), Blood Brain Barrier, Concentration Check, Dose Validation and most recently, our proprietary Fragment Based Screening assay. We use miniaturized gold standard shake flask methods, no predicting, no guessing, just high quality data, early in the discovery process.
ANALIZA, Inc. has provided cost effective Phsychem services to discovery and early-development Phsychem scientists since 1997. As the developer of the Automated Discovery Workstation, we have developed reliable, robust, automated, high-throughput methods for LogD, Aqueous Solubility, and BBB permeation. So your scientists can focus on important matters, like using our quality data to determine which drugs should move forward.
Using our proprietary Automated Discovery Workstation and universal method of detection, we are able to offer archival-quality data based on accurate, high-throughput, shake-flask LogD and aqueous solubility assays.
So whether you need to test only a few or thousands of compounds, Analiza can provide a solution.
Quality data
Achieved using miniaturized versions of gold standard shake-flask methods.
Flexibility
- Dry or DMSO-dissolved compounds
- Single or multiple pH levels
- Single or multiple co-solvents
Reliability
- Aqueous solubility: lower limit below 0.1µg/mL, with no practical upper limit
- LogD: dynamic range covers –3 < LogD < +4 compound specific
Analiza partners with discovery scientists at start-up biotech and big pharma alike to provide archival-quality Phsychem data at a fraction of the typical cost. Our innovative, universal method of detection eliminates the most time-consuming and costly parts of any assay - construction of a standard calibration curve for each compound and method development. So you get accurate, affordable assays, fast.
Think you can’t afford to outsource your aqueous solubility and LogD and BBB permeability testing?
At $100 or less per data point, you can’t afford not to.
Our Process
Automated Discovery Workstation (ADW)
- LogD (vs. pH) using miniaturized shake-flask technique for samples in DMSO
- Aqueous solubility (vs. pH) using miniaturized shake-flask technique for samples either dry or in DMSO
- Blood-brain barrier passive permeability
- Free/bound albumin-binding fraction
- Dosage validation for in vitro biological assays (NEW)
- Library concentration check without standards
ADW is the key to confidence in your data:
- True methods for accurate and reliable data: archival-quality data with the same meaning throughout discovery and development
- Automation in 96-well plates with standardized reagents
- Unique, equimolar quantification for standard-free, accurate, fast assays
- A tried and tested process with tens of thousands of assays over 7 years
