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Fast, Accurate and Affordable…

Focused on early discovery, we understand that compounds at this stage often suffer from low aqueous solubility and high non-specific binding. That’s why we don’t assume that compounds are fully soluble under the assay conditions nor do we rely on assumed mass balance. Instead, wth just 20 µL of 10mM DMSO stock solution we measure actual dose concentration at T0 along with the concentration in the donor and acceptor wells.

To avoid non-specific binding we’ve incorporated BD Gentest™ pre-coated PAMPA plates into our workflow. Unlike traditional PAMPA formulations, these plates are comprised of an oil-lipid-oil trilayer offering a shortened path for compound diffusion more closely mimicking diffusion across the cell membrane while minimizing non-specific binding and improving the accuracy of PAMPA permeability values for compounds that are typically under-predicted using traditional PAMPA methods.

Assay Protocol


  • Parallel Artificial Membrane Permeability using the BD GentestTM pre-coated PAMPA plate system.

Compound Requirements

  • 20 µL of 10mM DMSO stock solution

Dose Concentration

  • 200 µM (others available)

Incubation Time

  • 5 hours (others available)

Assay Media

  • PBS, pH 7.4
  • Other media available

Quantitation Method

  • CLND

Data Delivery within 72 hours

  • Papp
  • C0
  • % Retained


  • CLND: $50.00 per compound per media
  • HPLC-UV: $125.00 per compound
BD Gentest™ pre-coated PAMPA Plate Systems
72 Hours
Guaranteed turn around time after receiving your compound
starting price
of 10mM DMSO stock solution

Physchem Services •  LogD / Log P •  Aqueous Solubility •  pKa •  Chemical Stability •  XRPD •  Accurate Mass
ADME Services •  Microsomal Stability •  CYP450 Inhibition •  PAMPA •  BBB Permeability
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