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Chemical Stability

Fast, Accurate and Affordable…

Whether you’re tight on budget, time, or internal capacity, Analiza offers a Chemical Stability study to meet your discovery needs. We understand that different therapeutic areas and programs have different needs so we’ll work with you to identify the right screening strategy for you; maximizing your budget while enabling you to identify compound liabilities in real time.

Highly unstable compounds can lead to ambiguous in vitro biological data and may not be suitable candidates for development. Our automated short-term chemical stability assay mimics the short gastrointestinal transit time and in vitro biology conditions delivering Stability-pH profiles in just 72 hours or less. On this time scale project teams can not only identify liabilities and avoid ambiguous data but also develop appropriate compound modification strategies before the compounds progresses.


Assay Protocol

Compound Requirements

  • 25 µL of 10mM stock solution

Test Compound Concentration

  • 100 µM

Time Points

  • 0, 30, 60, 1440 min (other times available)

Assay Media

  • SGF, pH 1.2
  • SIF, pH 6.5
  • PBS, pH 7.4
  • Universal Buffer, pH 9.0
  • Other media available upon request

Incubation Temperatures

  • Ambient
  • 37°C

Analysis Method

  • LC-UV

Data Delivery within 72 hours

  • % Parent compound remaining at each time point

Cost

  • Screening: $50.00 per time point per media
  • Method Development: $100.00 per compound
At-a-glance
Target
Method
LC-UV
Target
72 Hours
Guaranteed turn around time after receiving your compound
Target
$100
starting price
Target
25µL
of 10mM DMSO stock solution

Physchem Services •  LogD / Log P •  Aqueous Solubility •  pKa •  Chemical Stability •  XRPD •  Accurate Mass
ADME Services •  Microsomal Stability •  CYP450 Inhibition •  PAMPA •  BBB Permeability
Sample Submission •  About •  Contact