HPLC-logD7.4Physicochemical Properties

logD

Whether you’re tight on budget, time, or internal capacity, Analiza offers a logD assay to meet your needs—especially if you’re breaking into new chemical space.  To meet the short timelines and scarce compound availability associated with discovery operations, we now offer a sophisticated HPLC-based alternative to the shake-flask method, built on the work of Lombardo et al. (J.Med. Chem. 2001, 44, 2490-2497) and specially designed with an extended dynamic range (-1 < logD < 6.1).

Our assay provides robust reproducibility while yielding true liphophilicity values for your compounds. Enjoy the peace of mind that comes with knowing that our HPLC methods help eliminate problems with impurities, solubility, sample quantity, and detection limits.

Let us leverage our expertise to design a screening strategy that is right for you.

assay requirements

Compound Requirements

  • 15 μL of 10 mM DMSO stock solution
  • Basic or neutral analyte
  • logD predicted values (optional)

Dose Concentration

  • 1 mM (others available)

Analytical Range

  • -1 ≤ logD ≤ 6.1

Quantitation Method

  • HPLC-UV

Results Delivered

  • logD

Cost

  • Quotes available on request

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