Plasma Stability

Assay information

Compound Requirements

10μL 10 mM DMSO stock

Time Points

Screening: 0 and 15, 30, or 60 min.
Half Life: 0, 15, 30, 60, and 120 min.

Species

Rat
Mouse
Dog
Human

Analysis Method

HPLC-MS

Data Delivery

Screening: Percent Remaining
Half Life: Intrinsic Clearance

Poor plasma stability can lead to rapid clearance, short half-lives, and poor in-vivo performance

Poor plasma stability can lead to rapid clearance, short half-lives, and poor in-vivo performance. Pharmacokinetic studies are especially challenging for these compounds as they continue to degrade even after blood is sampled from the study animal, leading to ambiguous data. In the case of prodrugs and antedrugs, rapid degradation in plasma is desirable.

If your compounds contain these plasma-labile functional groups, plasma stability should be studied:

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