XRD Crystallinity
Assay information
Compound Requirements
2mg dry powder
Analysis Method
Bruker D8 Powder X-ray diffractometer
2-theta range from 4 to 40 degrees
Step size: 0.01 degrees
Step time: 1 second
Data Delivery
Intensity (CPS)
Plot of Intensity as a function of degree
Avoid downstream surprises and costly development delays due to ambiguous solubility measurements
Data should be accurate and unambiguous even during discovery. XRD Crystallinity analysis can avoid downstream surprises and costly development delays due to ambiguous solubility measurements but is often not obtainable during discovery due to the mg quantities of material required for analysis. We’ve scaled back the requirements to 2mg, which can be reclaimed for subsequent solubility analysis.
True solubility of a substance is the solubility of its most stable form in equilibrium with the solvent; an amorph will have significantly higher apparent solubility than any of its crystalline forms. When thermodynamic solubility data is obtained on early discovery compounds, the measured solubility is often artificially high due to their amorphous nature, which can ultimately lead to ambiguous in-vitro and in-vivo data.
Contact us to learn more about our capabilities or to get a quote for your project.