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November 14 & 15, 2022 - Online via Zoom

Physicochemical
properties
workshop

Strategies, Tools, and Perspectives for Property-Based Drug Design

Welcome to the 4th annual Physicochemical Properties Workshop! The goal of this event is to gather industry professionals to advance the development of the science of physicochemical properties and to promote the exchange and circulation of information relating to measuring them, predicting them, and using data to make informed decisions. Our hope is that this workshop will foster interaction among attendees and create opportunities for research collaborations.

Speakers

Paul Leeson, Ph.D.

Paul Leeson Consulting, Ltd.

Laurence Philippe-Venec, Ph.D.

PIC Analytics

Giacomo Russo, Ph.D.

Edinburgh Napier University

Rob J. Young, Ph.D.

Blue Burgundy

Schedule

Monday, November 14th, 2022

Monday, November 14th, 2022

Time

Session

Speaker

11:00am - 11:10pm

Workshop Introduction

11:10am - 11:40am

"Drug-like” Properties: Which are Useful and Which are Not?

Paul Leeson, Ph.D.

Chemistry Consultant

11:50am - 12:50pm

Roundtable Discussions

1:00pm - 1:30pm

Lipophilicity by HPLC: a journey of interactions towards a better knowledge of Physicochemical Descriptors

Laurence Philippe-Venec, Ph.D.

Chemistry Consultant

Tuesday, November 15th, 2022

Tuesday, November 15th, 2022

Time

Session

Speaker

11:00am - 11:30am

Can biomimetic liquid chromatography assist in unveiling the absorption potential of new drug candidates?

Giacomo Russo, Ph.D.

Lecturer in Pharmaceutical Sciences

11:40am - 12:40pm

Roundtable Discussions

12:50pm - 1:20pm

Physicochemical design in the era of AI/machine learning – keep it simple, stupid?

Rob J. Young, Ph.D.

Chemistry Consultant

11:00am - 11:10pm

Workshop Conclusion

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info@analiza.com

Analiza, Inc.

3615 Superior Ave. E #4407B

Cleveland, OH 44114 

© All Rights Reserved 2022

info@analiza.com

Analiza, Inc.

3615 Superior Ave. E #4407B

Cleveland, OH 44114 

© All Rights Reserved 2022

© Copyright 2022


Analiza, Inc.
3615 Superior Ave. E #4407B
Cleveland, OH 44114
(216)432-9050
info@analiza.com

Paul Leeson, Ph.D.

Consultant

Paul Leeson Consulting Ltd.

Paul Leeson is a medicinal chemistry consultant with >35 years’ experience in major pharmaceutical companies: Smith Kline and French, Merck Sharp and Dohme, Wyeth (USA), AstraZeneca, and GlaxoSmithKline. Since 2014 he has advised pharmaceutical companies, start-ups, and academia. At AstraZeneca (1997-2011) Paul was head of medicinal chemistry at the Charnwood site and he led AstraZeneca’s Global Chemistry Forum, holding accountability for the company’s chemistry strategy. Paul’s drug discovery contributions have been in the cardiovascular, neuroscience, respiratory and inflammation therapy areas. He has a special interest in compound quality and in 2014 he received the Nauta Award from the European Federation of Medicinal Chemistry. Paul has a PhD from the University of Cambridge and holds an honorary professorship at the University of Nottingham.

Laurence Philippe-Venec, Ph.D.

Consultant

PIC Analytics

Laurence Philippe-Venec obtained her PhD in Analytical Chemistry and Separation Sciences from Pierre and Marie Curie University in Paris, France. She has over 28 years of experience in Analytical Chemistry and a Regulatory Affairs Professionals Certificate in Pharmaceuticals. She established her company, PIC Analytics, in 2018 to provide guidance for the characterization and development of drug compounds as an independent consultant.

Giacomo Russo, Ph.D.

Lecturer

Edinburgh Napier University

Dr. Giacomo Russo achieved in 2012 a master’s degree in “Chemistry and Pharmaceutical Technology” summa cum laude from University of Naples Federico II. In 2013, he was kindly asked to join the Pharm-Analysis & Bio-Pharm Laboratory from the same University for a Ph.D. in Pharmaceutical Sciences, which he completed (grade: Excellent) in 2016. During his Ph.D. studies, he worked for three months in 2015 as visiting Ph.D. candidate at the Drug Design Laboratories of the University of Milan “Statale” headed by Prof. Dr. Alessandro Pedretti and Prof. Dr. Giulio Vistoli, where he got hand-on experience and practical training in Computational Chemistry and Chemometrics. At the end of the same year, he was accepted as visiting Ph.D. candidate at the Separation Science Group (SSG), University of Ghent (UGent) (Belgium) for conducting biopartitioning studies for seven months in the state-of-the-art analytical laboratories led by Prof. Frederic Lynen. Dr. Giacomo Russo conducted post-doctoral research in nanoplasmonics and microcalorimetry at the Department of Chemistry, University of Helsinki (Finland) for 5 months in 2016 with the supervision of Prof. Dr. Susanne Kristina Wiedmer. He then was involved in other postdoctoral studies in formulation of a novel manganese superoxide dismutase with antitumoral activity in highly selective and biocompatible polymeric assemblies. This project was a joint activity involving the University of Palermo (supervisor: Prof. Massimo Midiri), the Italian Institute of Technology (supervisor: Ing. Raffaele Vecchione) and the University of Naples Federico II (supervisor: Prof. Lucia Grumetto). From August 2018, Dr. Russo joined again the SSG for innovative research concerning 3D printing and multidimensional gas and liquid chromatography for 1.5 years. After 3 and half year from the completion of his Ph.D., Dr. Giacomo Russo got a permanent lectureship in Pharmaceutical Sciences at Edinburgh Napier University, Edinburgh (UK). Dr. Russo currently co-authored 30 original papers, 1 review article, 9 posters and gave 9 oral communications at national and international conferences. He got 4 awards (of which 2 best poster awards). He is also active as reviewer (average 1 paper/month from Pharmaceutical Sciences and Analytical Chemistry journals) and expert for the National Science Poland (call PRELUDIUM). He was included in December 2019 in the list of Rising Stars of Separation Science by the journal LC GC Europe.

Rob J. Young, Ph.D.

Consultant

Blue Burgundy

Rob joined Wellcome on Valentine’s day in 1990, following BA/DPhil degrees at University of Oxford and Post Doc at Ben May Institute, University of Chicago. His subsequent career navigated changes, mergers and acquisitions and positions of increasing responsibility to become a Scientific Leader and elected GSK Fellow. Early career charted significant contributions to six development candidates in antivirals (HIV/HBV/Herpes), iNOS and Factor Xa, before a move to early stage discovery (2006) fulfilling leadership roles numerous H2L programs, using diverse technologies including HTS, fragments, focussed & designed screens and DNA-encoded libraries. Substantive transnational working included close ties with the GSK Diseases of the Developing World group in Spain encompassing leadership of several H2L programmes, plus mentoring and SAB roles. Expertise in Physical Properties and the Property Forecast Index were developed in a productive partnership with Alan Hill spanning many years, instrumental in setting new standards in drug discovery with chromatographic methods. Appointed/co-opted to numerous GSK cross-disciplinary initiatives and communities including in silico predictive modelling, DMPK, Physical Chemsitry, Stability and Safety. Author/inventor on over 100 publications/ patent applications and an honorary visiting Professor, University of St Andrews.
Rob took early retirement from GSK in July 2019 and set up Blue Burgundy to pursue medicinal chemistry consulting and educational interests.