Physicochemical Properties
Early-stage drug discovery hinges on accurate, high-quality data about each compound’s fundamental characteristics. At Analiza, we’ve miniaturized and automated gold-standard assays to measure solubility, logD/logP, pKa, and more—providing quick, reliable insights that guide your pipeline decisions.
Why Physicochemical Data Matters
Physicochemical properties shape how a molecule behaves in both in-vitro and in-vivo environments. By understanding factors like solubility, lipophilicity, and pKa, you can optimize a compound’s efficacy, formulation, and safety profile far earlier in the development process.
Physicochemical Property Assays
pKa
Using capillary electrophoresis, we can determine a compound’s ionization constants even for low-solubility molecules. Knowing your compound’s pKa is crucial for predicting solubility, permeability, and overall ADME performance in various pH environments.
Solubility
We use a miniaturized shake-flask approach for thermodynamic solubility, quantifying results with CLND, HPLC-UV, or HPLC-MS. With as little as 15 μL of 10 mM stock, this assay yields precise measurements that help predict in-vitro success and ensure clean downstream data.
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Contact our team today to see how Analiza can accelerate your drug discovery program.